Systemic lupus erythematosus

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An excellent review

Authors: Larissa Lisnevskaia, Grainne Murphy, David Isenberg

Lancet 2014; 384: 1878–88

Abstract: Systemic lupus erythematosus is a remarkable and challenging disorder. Its diversity of clinical features is matched
by the complexity of the factors (genetic, hormonal, and environmental) that cause it, and the array of autoantibodies
with which it is associated. In this Seminar we refl ect on changes in its classifi cation criteria; consider aspects of its
more serious clinical expression; and provide a brief review of its aetiopathogenesis, major complications, coping
strategies, and conventional treatment. Increased understanding of the cells and molecules involved in the
development of the diseases has encouraged the identifi cation of new, better targeted biological approaches to its
treatment. The precise role of these newer therapies remains to be established.

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