An interesting review from two Masters of Rheumatology. Are we close to cure Rheumatoid Arthritis? Don’t miss it
Marc Feldmann and Ravinder N. Maini
Article first published online: 26 AUG 2015
We have lived through amazing times in rheumatology, with progress in drug discovery based on intuition (e.g., gold, sulfasalazine) to discovery driven by advances in understanding of the molecular basis of disease pathogenesis and application of technology, chiefly based on molecular biology and immunology. When we were medical students autoimmunity was a vague concept, inflammatory mediators were a few small chemicals, cellular signaling was a mystery, and therapeutics was dominated by the organic medicinal chemists. Rheumatoid arthritis (RA) was an incurable, painful, life-damaging, and life-shortening disease  for which prior attempts at a cure, as with the lauded discovery of corticosteroids, ended lamentably . But through empiricism, there was progress, even without access to modern technological tools.
There has been considerable further progress, with breakthroughs in the understanding of…………